The Anti-Apoptotic Role of Neuroglobin

The Anti-Apoptotic Role of Neuroglobin

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The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the GF MUESLI rod cells of the retina.This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death.The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c.An integrated model, based on the various molecular actions of both neuroglobin and cytochrome Ski de fond - Enfant - Skis - Classic c, is developed, which accounts for the cellular distribution of neuroglobin.